海外の腸内細菌に関する資料リスト【論文・研究情報】

海外では、早くから細菌研究（マイクロバイオーム）に莫大な投資を行い、優秀な研究者たちが日夜研究を進めています。

日本は遅れていると言わざるを得ないのが現状ですが、海外の論文からは学ぶことがたくさんあります。世界の研究者たちが手を携え、知識や知恵を持ち寄りながら医療の発展に寄与することが望まれます。

海外の腸内細菌に関する資料リスト

・Alterations of the human gut microbiome in multiple sclerosis
Nature Communications 　28 June 2016

・Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system
31　July 2017

・Brain structure and response to emotional stimuli as related to gut microbial profiles in healthy women
1 October 2018

・Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis | Nature Microbiology
14 January 2019

・Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study | Microbiome | Full Text
23 January 2019

・The neuroactive potential of the human gut microbiota in quality of life and depression | Nature Microbiology
04　February 2019

・Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity | Nature Microbiology
04 March 2019

・Autism symptoms reduced nearly 50 percent two years after fecal transplant
・Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota | Scientific Reports
09 April 2019

・Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice. – PubMed – NCBI
30　May 2019

・Predictive metabolomic profiling of microbial communities using amplicon or metagenomic sequences
Nature Communications 　17 July 2019

・Infant gut microbiota and food sensitization: associations in the first year of life
iley Online Library 　20 January 2015

・Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant
Science Translational Medicine 　26 Sep 2018

・Effect of Oral Capsule– vs Colonoscopy-Delivered Fecal Microbiota Transplantation on Recurrent Clostridium difficile Infection
JAMA 　28 November 2017

・The brave new world of DIY faecal transplant
BBC News　27 May 2014

・The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
Nature　Published: 07 May 2013
※日本語版：腸内細菌叢はインスリンの作用による脂肪の蓄積を短鎖脂肪酸受容体GPR43を介して抑制する

・Human gut microbes impact host serum metabolome and insulin sensitivity
Nature　Published: 13 July 2016
※日本語版：腸内細菌と宿主のインスリン感受性

・The effect of fecal microbiota transplantation on psychiatric symptoms among patients with irritable bowel syndrome, functional diarrhea and functional constipation: An open-label observational study.
2018 Aug 1
（内容）過敏性腸症候群、下痢、便秘の患者へのFMT試験

・Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring
Nature　Published: 13 September 2017
※日本語版：母体の腸内細菌は仔マウスに神経発達障害を促進する

・The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus
Nature Neuroscience　09 July 2018

・The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation
PubMed – NCBI　2014 Aug 14

・Bifidobacteria can protect from enteropathogenic infection through production of acetate.
PubMed – NCBI　2011 Jan 27

・Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors　Science　2018.1.5

・Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity　PNAS　2013.5.28

・Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium　Microbiology Society Journals　2004.9.01

・How gut microbes are joining the fight against cancer　nature　23 MAY 2018

・Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota
Published online 2014 May 6

・Dysbiosis of Salivary Microbiota in Inflammatory Bowel Disease and Its Association With Oral Immunological Biomarkers
Published online 2013 Sep 7

・Gut feeling: How intestinal bacteria may influence our moods
CBC News　July 15, 2014

・Fecal microbiota transplantation produces sustained improvements in cognitive and clinical outcomes
— ScienceDaily　April 14, 2018

・Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
Els van Nood, M.D., Anne Vrieze, M.D., Max Nieuwdorp, M.D., Ph.D., Susana Fuentes, Ph.D., Erwin G. Zoetendal, Ph.D., Willem M. de Vos, Ph.D., Caroline E. Visser, M.D., Ph.D., Ed J. Kuijper, M.D., Ph.D., Joep F.W.M. Bartelsman, M.D., Jan G.P. Tijssen, Ph.D., Peter Speelman, M.D., Ph.D., Marcel G.W. Dijkgraaf, Ph.D., et al.

・Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers
Cancer Research
Brandilyn A. Peters, Jing Wu, Zhiheng Pei, Liying Yang, Mark P. Purdue, Neal D. Freedman, Eric J. Jacobs, Susan M. Gapstur, Richard B. Hayes and Jiyoung Ahn
DOI: 10.1158/0008-5472.CAN-17-1296 Published December 2017

・The Gut Microbiota of Healthy Aged Chinese Is Similar to That of the Healthy Young
Gaorui Bian, Gregory B. Gloor, Aihua Gong, Changsheng Jia, Wei Zhang, Jun Hu, Hong Zhang, Yumei Zhang, Zhenqing Zhou, Jiangao Zhang, Jeremy P. Burton, Gregor Reid, Yongliang Xiao, Qiang Zeng, Kaiping Yang, Jiangang Li

・Microbiota alteration is associated with the development of stress-induced despair behavior
Jonathan Kipnis & Alban Gaultier 07 March 2017

・Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial
Lancet. 2017 Mar 25;389(10075):1218-1228. doi: 10.1016/S0140-6736(17)30182-4. Epub 2017 Feb 15.

・Synbiotics for Prevention and Treatment of Atopic Dermatitis
Yung-Sen Chang, MD, MPH1; Michelle K. Trivedi, MD, MPH2,3; Ayan Jha, MBBS, MPH4; et al　March 2016
（日本語訳：シンバイオティクスはアトピー性皮膚炎の治療に有効か？メタアナリシスでの結論｜Mykinsoラボ）

・Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives

・Fecal microbiota transplantation in children: a brief review | Pediatric Research

・The Fecal Transplant: Can It Help Colitis, Candida, IBS and More?
Fecal Transplants for Colitis, Candida and IBS – Dr. Axe

・High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome
『Gut 2015年9月28日号』 online版

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ちひろ

自分の目で見えて、自分の手で触れられるものしか信じてきませんでした。 でも、目には見えないほど小さな微生物たちがこの世界には存在していて、彼らがわたしたちの毎日を守ってくれているのだと知りました。 いくつになっても世界は謎で満ちていて、ふたを開けると次は何が出てくるんだろう、とわくわくしながら暮らしています。

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