海外では、早くから細菌研究(マイクロバイオーム)に莫大な投資を行い、優秀な研究者たちが日夜研究を進めています。
日本は遅れていると言わざるを得ないのが現状ですが、海外の論文からは学ぶことがたくさんあります。
世界の研究者たちが手を携え、知識や知恵を持ち寄りながら医療の発展に寄与することが望まれます。
・The brave new world of DIY faecal transplant
BBC News 27 May 2014
・The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
Nature Published: 07 May 2013
※日本語版:腸内細菌叢はインスリンの作用による脂肪の蓄積を短鎖脂肪酸受容体GPR43を介して抑制する
・Human gut microbes impact host serum metabolome and insulin sensitivity
Nature Published: 13 July 2016
※日本語版:腸内細菌と宿主のインスリン感受性
・The effect of fecal microbiota transplantation on psychiatric symptoms among patients with irritable bowel syndrome, functional diarrhea and functional constipation: An open-label observational study.
2018 Aug 1
(内容)過敏性腸症候群、下痢、便秘の患者へのFMT試験
・Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring
Nature Published: 13 September 2017
※日本語版:母体の腸内細菌は仔マウスに神経発達障害を促進する
・The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus
Nature Neuroscience 09 July 2018
・The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation
PubMed – NCBI 2014 Aug 14
・Bifidobacteria can protect from enteropathogenic infection through production of acetate.
PubMed – NCBI 2011 Jan 27
・Fecal Transplant Success Stories(★移植体験談) The Power Of Poop
・Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors Science 2018.1.5
・Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity PNAS 2013.5.28
・Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium Microbiology Society Journals 2004.9.01
・How gut microbes are joining the fight against cancer nature 23 MAY 2018
・Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota
Published online 2014 May 6
・Dysbiosis of Salivary Microbiota in Inflammatory Bowel Disease and Its Association With Oral Immunological Biomarkers
Published online 2013 Sep 7
・Gut feeling: How intestinal bacteria may influence our moods
CBC News July 15, 2014
・Fecal microbiota transplantation produces sustained improvements in cognitive and clinical outcomes
— ScienceDaily April 14, 2018
・Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
Els van Nood, M.D., Anne Vrieze, M.D., Max Nieuwdorp, M.D., Ph.D., Susana Fuentes, Ph.D., Erwin G. Zoetendal, Ph.D., Willem M. de Vos, Ph.D., Caroline E. Visser, M.D., Ph.D., Ed J. Kuijper, M.D., Ph.D., Joep F.W.M. Bartelsman, M.D., Jan G.P. Tijssen, Ph.D., Peter Speelman, M.D., Ph.D., Marcel G.W. Dijkgraaf, Ph.D., et al.
・Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers
Cancer Research
Brandilyn A. Peters, Jing Wu, Zhiheng Pei, Liying Yang, Mark P. Purdue, Neal D. Freedman, Eric J. Jacobs, Susan M. Gapstur, Richard B. Hayes and Jiyoung Ahn
DOI: 10.1158/0008-5472.CAN-17-1296 Published December 2017
・The Gut Microbiota of Healthy Aged Chinese Is Similar to That of the Healthy Young
Gaorui Bian, Gregory B. Gloor, Aihua Gong, Changsheng Jia, Wei Zhang, Jun Hu, Hong Zhang, Yumei Zhang, Zhenqing Zhou, Jiangao Zhang, Jeremy P. Burton, Gregor Reid, Yongliang Xiao, Qiang Zeng, Kaiping Yang, Jiangang Li
・Microbiota alteration is associated with the development of stress-induced despair behavior
Jonathan Kipnis & Alban Gaultier 07 March 2017
・Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial
Lancet. 2017 Mar 25;389(10075):1218-1228. doi: 10.1016/S0140-6736(17)30182-4. Epub 2017 Feb 15.
・Synbiotics for Prevention and Treatment of Atopic Dermatitis
Yung-Sen Chang, MD, MPH1; Michelle K. Trivedi, MD, MPH2,3; Ayan Jha, MBBS, MPH4; et al March 2016
(日本語訳:シンバイオティクスはアトピー性皮膚炎の治療に有効か?メタアナリシスでの結論|Mykinsoラボ)
・Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives
・Fecal microbiota transplantation in children: a brief review | Pediatric Research
・The Fecal Transplant: Can It Help Colitis, Candida, IBS and More?
Fecal Transplants for Colitis, Candida and IBS – Dr. Axe
・High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome
『Gut 2015年9月28日号』 online版